Scientific Articles

Osteoarthritis

Crema MD, Watts GJ, Guermazi A, Kim YJ, Kijowski R, Roemer FW. A narrative overview of the current status of MRI of the hip and its relevance for osteoarthritis research - what we know, what has changed and where are we going? Osteoarthritis Cartilage. 2017:1-13.

Jarraya M, Roemer FW, Englund M, Crema MD, Gale HI, Hayashi D, Katz JN, Guermazi A. Meniscus morphology: Does tear type matter? A narrative review with focus on relevance for osteoarthritis research. Semin Arthritis Rheum. 2016 Nov 24.

Guermazi A, Hayashi D, Roemer FW, Niu J, Quinn EK, Crema MD, Nevitt MC, Torner J, Lewis CE, Felson DT. Partial- and Full-thickness focal cartilage defects equaly contribute to development of new cartilage damage in knee

Roemer FW, Aydemir A, Lohmander S, Crema MD, Marra MD, Muurahainen N, Felson DT, Eckstein F, Guermazi A. Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial. BMC Musculoskelet Disord 2016;17:267.

Kim IJ, Kim DH, Song YW, Guermazi A, Crema MD, Hunter DJ, Seo YI, Kim HA. The prevalence of periarticular lesions detected on magnetic resonance imaging in middle-aged and elderly persons: a cross-sectional study. BMC Musculoskelet Disord. 2016;17:186.

Guermazi A, Crema MD, Roemer FW. Compositional Magnetic Resonance Imaging Measures of Cartilage--Endpoints for Clinical Trials of Disease-modifying Osteoarthritis Drugs? J Rheumatol. 2016;43(1):7-11

Roemer FW, Jarraya M, Felson DT, Hayashi D, Crema MD, Loeuille D, Guermazi A. Magnetic resonance imaging of Hoffa's fat pad and relevance for osteoarthritis research: a narrative review. Osteoarthritis Cartilage. 2016;24(3):383-97.

Roemer FW, Hunter DJ, Crema MD, Kwoh CK, Ochoa-Albiztegui E, Guermazi A. An illustrative overview of semi-quantitative MRI scoring of knee osteoarthritis: lessons learned from longitudinal observational studies. Osteoarthritis Cartilage. 2016;24(2):274-89.

Guermazi A, Crema MD, Roemer FW. Compositional magnetic resonance imaging measures of cartilage – endpoints for clinical trials of disease-modifying osteoarthritis drugs? J Rheumatol 2016;43:7-11.

Roemer FW, Hunter DJ, Crema MD, Kwoh CK, Ochoa-Albiztegui E, Guermazi A. Na illustrative overview of semiquantitative MRI scoring of the knee osteoarthritis: lessons learned from longitudinal observational studies. Osteoarthritis Cartilage 2016;24:274-89.

Guermazi A, Alizai H, Crema MD, Trattnig S, Regatte RR, Roemer FW. Compositional MRI techniques for evaluation of cartilage degeneration in osteoarthritis. Osteoarthritis Cartilage 2015;23:1639-53.

 

Bloecker K, Wirth W, Guermazi A, Hunter DJ, Resch H, Hochreiter J, Eckstein F. Medial meniscal extrusion relates to cartilage loss in specific femorotibial subregions- data from the osteoarthritis initiative. Arthritis Care Res (Hoboken) 2015 May 18 [Epub ahead of print]

 

Hunter DJ, Arden N, Cicuttini F, Crema MD, Dardzinski B, Duryea J, Guermazi A, Haugen IK, Kloppenburg M, Maheu E, Miller CG, Martel-Pelletier J, Ochoa-Albíztegui RE, Pelletier JP, Peterfy C, Roemer F, Gold GE. OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis. Osteoarthritis Cartilage 2015; 23: 732-746.

 

Gold GE, Cicuttini F, Crema MD, Eckstein F, Guermazi A, Kijowski R, Link TM, Maheu E, Martel-Pelletier J, Miller CG, Pelletier JP, Peterfy CG, Potter HG, Roemer FW, Hunter DJ. OARSI Clinical Trials Recommendations: Hip imaging in clinical trials in osteoarthritis. Osteoarthritis Cartilage 2015; 23:716-731.

 

Hunter DJ, Altman RD, Cicuttini F, Crema MD, Duryea J, Eckstein F, Guermazi A, Kijowski R, Link TM, Martel-Pelletier J, Miller CG, Mosher TJ, Ochoa-Albíztegui RE, Pelletier JP, Peterfy C, Raynauld JP, Roemer FW, Totterman SM, Gold GE. OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis. Osteoarthritis Cartilage 2015; 23: 698-715.

 

Roemer FW, Kwoh CK, Hannon MJ, Hunter DJ, Eckstein F, Fujii T, Boudreau RM, Guermazi A. What comes first? Multi-tissue involvement leading to radiographic osteoarthritis: MRI-based trajectory analysis over 4 years in the Osteoarthritis Initiative. Arthritis Rheumatol 2015 May 4 [Epub ahead of print]

 

Guermazi A, Hayashi D, Roemer F, Felson DT, Wang K, Lynch J, Amin S, Torner J, Lewis CE, Nevitt MC. Severe radiographic knee osteoarthritis - does Kellgren and Lawrence grade 4 represent end stage disease? - The MOST study. Osteoarthritis Cartilage 2015 Apr 28 [Epub ahead of print]

 

Culvenor AG, Collins NJ, Guermazi A, Cook JL, Vicenzino B, Khan KM, Crossley KM. The incidence rate of early knee osteoarthritis one year following anterior cruciate ligament reconstruction was overestimated or not? (Reply to letter to the editor) Arthritis Rheumatol 2015 Apr 27 [Epub ahead of print] 

 

Hunter DJ, Beavers DP, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko SL, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP. The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes. Osteoarthritis Cartilage 2015 Apr 15 [Epub ahead of print]

 

Bloecker K, Wirth W, Guermazi A, Hitzl W, Hunter DJ, Eckstein F. Longitudinal change in quantitative meniscus measurements in knee osteoarthritis-data from the Osteoarthritis Initiative. Eur Radiol 2015 Mar 24 [Epub ahead of print]

 

Roemer FW, Jarraya M, Kwoh CK, Hannon MJ, Boudreau RM, Green SM, Jakicic JM, Moore C, Guermazi A. Symmetricity of radiographic and MRI-detected structural joint damage in persons with knee pain - the Joints on Glucosamine (JOG) Study. Osteoarthritis Cartilage 2015 Mar 6 [Epub ahead of print]

 

Johnson VL, Kwoh CK, Guermazi A, Roemer F, Boudreau RM, Fujii T, Hannon MJ, Hunter DJ. Loss of anterior cruciate ligament integrity and the development of radiographic knee osteoarthritis: a sub-study of the osteoarthritis initiative. Osteoarthritis Cartilage 2015; 23: 882-887

 

Culvenor AG, Collins NJ, Guermazi A, Cook JL, Vicenzino B, Khan KM, Beck N, van Leeuwen J, Crossley KM. Early knee osteoarthritis is evident one year following anterior cruciate ligament reconstruction: A magnetic resonance imaging evaluation. Arthritis Rheumatol 2015; 67: 946-955.

 

Chang AH, Moisio KC, Chmiel JS, Eckstein F, Guermazi A, Prasad PV, Zhang Y, Almagor O, Belisle L, Hayes K, Sharma L. External knee adduction and flexion moments during gait and medial tibiofemoral disease progression in knee osteoarthritis. Osteoarthritis Cartilage 2015 Feb 10 [Epub ahead of print]

 

Guermazi A, Eckstein F, Hunter D, Roemer F. 7th International Workshop on Osteoarthritis Imaging report: "imaging in OA - now is the time to move ahead". Osteoarthritis Cartilage 2015; 23: 888-896.

 

Stefanik JJ, Gross KD, Guermazi A, Felson DT, Roemer FW, Zhang Y, Niu J, Segal NA, Lewis CE, Nevitt M, Neogi T. The relation of MRI-detected structural damage in the medial and lateral patellofemoral joint to knee pain: The Multicenter and Framingham Osteoarthritis Studies. Osteoarthritis Cartilage 2015; 23: 565-570.

 

Atukorala I, Kwoh CK, Guermazi A, Roemer FW, Boudreau RM, Hannon MJ, Hunter DJ. Synovitis in knee osteoarthritis: A precursor of disease? Ann Rheum Dis 2014 Dec 8 [Epub ahead of print]

 

Roemer FW, Jarraya M, Niu J, Silva JR, Frobell R, Guermazi A. Increased risk for radiographic osteoarthritis features in young active athletes: A cross-sectional matched case-control study. Osteoarthritis Cartilage 2014 Nov 15 [Epub ahead of print]

 

Roemer FW, Guermazi A. Osteoarthritis Year in Review 2014: Imaging. Osteoarthritis Cartilage 2014; 22: 2003-2012.

 

Alizai H, Roemer FW, Hayashi D, Crema MD, Felson DT, Guermazi A. An update on risk factors for cartilage loss in knee osteoarthritis assessed using MRI-based semiquantitative grading methods. Eur Radiol 2014 Nov 7 [Epub ahead of print]

 

Misra D, Guermazi A, Sieren JP, Lynch J, Torner J, Neogi T, Felson DT. CT imaging for evaluation of calcium crystal deposition in the knee: Initial experience from the Multicenter Osteoarthritis (MOST) study. Osteoarthritis Cartilage 2014 Nov 15 [Epub ahead of print]

 

Roemer FW, Kwoh CK, Hannon MJ, Hunter DJ, Eckstein F, Wang Z, Boudreau RM, John MR, Nevitt MC, Guermazi A. Can structural joint damage measured with MR imaging be used to predict knee replacement in the following year? Radiology 2014 Oct 3:140991 [Epub ahead of print]

 

Crema MD, Nevitt MC, Guermazi A, Felson DT, Wang K, Lynch JA, Marra MD, Torner J, Lewis CE, Roemer FW. Progression of cartilage damage and meniscal pathology over 30 months is associated with an increase in radiographic tibiofemoral joint space narrowing in persons with knee OA - the MOST study. Osteoarthritis Cartilage 2014; 22: 1743-1747.

 

Guermazi A, Roemer FW, Crema MD, Englund M, Hayashi D. Imaging of non-osteochondral tissues in osteoarthritis. Osteoarthritis Cartilage 2014; 22: 1590-1605.

 

Eckstein F, Guermazi A, Gold G, Duryea J, Hellio Le Graverand MP, Wirth W, Miller CG. Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis. Osteoarthritis Cartilage 2014; 22: 1516-1532.

 

Kim C, Linsenmeyer KD, Vlad S, Guermazi A, Clancy MM, Niu J, Felson DT. Prevalence of radiographic and symptomatic hip osteoarthritis in an urban US community: the Framingham Osteoarthritis Study. Arthritis Rheumatol 2014 Aug 7 [Epub ahead of print]

 

Suri P, Hunter DJ, Boyko EJ, Rainville J, Guermazi A, Katz JN. Physical activity and associations with computed tomography-detected lumbar zygapophyseal joint osteoarthritis. Spine J 2014 Jul 7 [Epub ahead of print]

 

Sharma L, Chmiel JS, Almagor O, Dunlop D, Guermazi A, Bathon JM, Eaton CB, Hochberg MC, Jackson RD, Kwoh CK, Mysiw WJ, Crema MD, Roemer FW, Nevitt MC. Significance of preradiographic magnetic resonance imaging lesions in persons at increased risk of knee osteoarthritis. Arthritis Rheumatol 2014; 66: 1811-1819.

 

Stefanik JJ, Neogi T, Niu J, Roemer FW, Segal NA, Lewis CE, Nevitt M, Guermazi A, Felson DT. The Diagnostic performance of anterior knee pain and activity-related pain in identifying knees with structural damage in the patellofemoral joint: The Multicenter Osteoarthritis Study. J Rheumatol 2014; 41: 1695-1702.

 

Hayashi D, Xu L, Gusenburg J, Roemer FW, Hunter DJ, Li L, Guermazi A. Reliability of semiquantitative assessment of osteophytes and subchondral cysts on tomosynthesis images by radiologists with different levels of expertise. Diagn Interv Radiol 2014; 20: 353-359.

 

Jarraya M, Hayashi D, Guermazi A, Kwoh CK, Hannon MJ, Moore CE, Jakicic JM, Green SM, Roemer FW. Susceptibility artifacts detected on 3T MRI of the knee: frequency, change over time and associations with radiographic findings: data from the Joints on Glucosamine Study. Osteoarthritis Cartilage 2014; 22: 1499-1503.

 

Roemer FW, Eckstein F, Hayashi D, Guermazi A. The role of imaging in osteoarthritis. Best Pract Res Clin Rheumatol 2014; 28: 31-60.

 

Eckstein F, Boudreau RM, Wang Z, Hannon MJ, Wirth W, Cotofana S, Guermazi A, Roemer F, Nevitt M, John MR, Ladel C, Sharma L, Hunter DJ, Kwoh CK; for the OAI investigators. Trajectory of cartilage loss within 4 years of knee replacement - a nested case-control study from the Osteoarthritis Initiative. Osteoarthritis Cartilage 2014; 22: 1542-1549.

 

Lohmander LS, Hellot S, Dreher D, Krantz EF, Kruger DS, Guermazi A, Eckstein F. Intra-articular Sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: Randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol 2014 Apr 17 [Epub ahead of print]

 

Duryea J, Iranpour-Boroujeni T, Collins JE, Vanwynngaarden C, Guermazi A, Katz JN, Losina E, Russell R, Ratzlaff C. Local-area cartilage segmentation (LACS) - A semi-automated novel method of measuring cartilage loss in knee osteoarthritis. Arthritis Care Res (Hoboken) 2014 Mar 24 [Epub ahead of print]

 

Roemer FW, Frobell R, Lohmander LS, Niu J, Guermazi A. Anterior Cruciate Ligament OsteoArthritis Score (ACLOAS): Longitudinal MRI-based whole joint assessment of anterior cruciate ligament injury. Osteoarthritis Cartilage 2014; 22: 668-682.

 

Kwoh CK, Roemer FW, Hannon MJ, Moore CE, Jakicic JM, Guermazi A, Green SM, Evans RW, Boudreau R. The Joints on Glucosamine (JOG) Study: The effect of oral glucosamine on joint structure, a randomized trial. Arthritis Rheumatol 2014; 66: 930-939.

 

Crema MD, Hunter DJ, Burstein D, Roemer FW, Li L, Krishnan N, Marra MD, Hellio Le-Graverand MP, Guermazi A. Delayed gadolinium-enhanced MRI of medial tibiofemoral cartilage and its relationship with meniscal pathology: A longitudinal study using 3.0T MRI. Arthritis Rheumatol 2014; 66: 1517-1524.

 

Crema MD, Cibere J, Sayre EC, Roemer FW, Wong H, Thorne A, Singer J, Esdaile JM, Marra MD, Kopec JA, Nicolaou S, Guermazi A. The relationship between subchondral sclerosis detected with MRI and cartilage loss in a cohort of subjects with knee pain: the knee osteoarthritis progression (KOAP) study. Osteoarthritis Cartilage 2014; 22: 540-546.

 

Bruns K, Svensson F, Turkiewicz A, Wirth W, Guermazi A, Eckstein F, Englund M. Meniscus body position and its change over four years in asymptomatic adults: a cohort study using data from the Osteoarthritis Initiative (OAI). BMC Musculoskelet Disord 2014; 15: 32.

 

Guermazi A, Hayashi D, Roemer FW, Zhu Y, Niu J, Crema MD, Javaid MK, Marra MD, Lynch JA, El-Khoury GY, Zhang Y, Nevitt MC, Felson DT. Synovitis in knee osteoarthritis assessed by contrast-enhanced magnetic resonance imaging (MRI) is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage: The MOST study. J Rheumatol 2014; 41: 501-508.

 

Hayashi D, Guermazi A, Kwoh CK. Clinical and translational potential of MRI evaluation in knee osteoarthritis. Curr Rheumatol Rep 2014; 16: 391. 

 

Bloecker K, Guermazi A, Wirth W, Kwoh CK, Resch H, Hunter DJ, Eckstein F; for the OAI investigators. Correlation of semiquantitative vs quantitative MRI meniscus measures in osteoarthritic knees: results from the Osteoarthritis Initiative. Skeletal Radiol 2014; 43: 227-232.

 

Hayashi D, Felson DT, Niu J, Hunter DJ, Roemer FW, Aliabadi P, Guermazi A. Pre-radiographic osteoarthritic changes are highly prevalent in the medial patella and medial posterior femur in older persons: Framingham OA Study. Osteoarthritis Cartilage 2014; 22: 76-83.

 

Sayre EC, Singer J, Thorne A, Wong H, Kopec JA, Esdaile JM, Guermazi A, Nicolaou S, Cibere J. Does moderate or severe nonspecific knee injury affect radiographic osteoarthritis incidence and progression? BMC Musculoskelet Disord 2013; 14: 309.

 

Bloecker K, Wirth W, Hunter DJ, Duryea J, Guermazi A, Kwoh CK, Resch H, Eckstein F. Contribution of regional 3D meniscus and cartilage morphometry by MRI to joint space width in fixed flexion knee radiography-A between-knee comparison in subjects with unilateral joint space narrowing. Eur J Radiol 2013; 82: e832-839.

 

Hayashi D, Xu L, Guermazi A, Kwoh CK, Hannon MJ, Jarraya M, Green SM, Jakicic JM, Moore CE, Roemer FW. Prevalence of MRI-detected mediopatellar plica in subjects with knee pain and the association with MRI-detected patellofemoral cartilage damage and bone marrow lesions: data from the Joints On Glucosamine study. BMC Musculoskelet Disord 2013; 14: 292.

 

Messier SP, Mihalko S, Legault C, Miller GD, Nicklas BJ, DeVita P, Beavers DP, Hunter DJ, Lyles MF, Eckstein F, Williamson JD, Carr JJ, Guermazi A, Loeser RF. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: The IDEA randomized clinical trial. JAMA 2013; 310: 1263-1273.

 

Kim IJ, Kim DH, Jung JY, Song YW, Guermazi A, Crema MD, Hunter DJ, Kim HA. Association between bone marrow lesions detected by magnetic resonance imaging and knee pain in community residents in Korea. Osteoarthritis Cartilage 2013; 21: 1207-1213. 

 

Suri P, Hunter DJ, Rainville J, Guermazi A, Katz JN. Presence and extent of severe facet joint osteoarthritis are associated with back pain in older adults. Osteoarthritis Cartilage 2013; 21: 1199-1206

 

Hunter DJ, Guermazi A, Roemer F, Zhang Y, Neogi T. Structural correlates of pain in joints with osteoarthritis. Osteoarthritis Cartilage 2013; 21: 1170-1178.

 

Mosher TJ, Walker EA, Petscavage-Thomas J, Guermazi A. Osteoarthritis year 2013 in review: imaging. Osteoarthritis Cartilage 2013; 21: 1425-1435.

 

Pelletier JP, Cooper C, Peterfy C, Reginster JY, Brandi ML, Bruyère O, Chapurlat R, Cicuttini F, Conaghan PG, Doherty M, Genant H, Giacovelli G, Hochberg MC, Hunter DJ, Kanis JA, Kloppenburg M, Laredo JD, McAlindon T, Nevitt M, Raynauld JP, Rizzoli R, Zilkens C, Roemer FW, Martel-Pelletier J, Guermazi A. What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis? Ann Rheum Dis 2013; 72: 1594-1604.

 

Crema MD, Hunter DJ, Burstein D, Roemer FW, Li L, Eckstein F, Krishnan N, Hellio Le-Graverand MP, Guermazi A. Association of changes in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) with changes in cartilage thickness in the medial tibiofemoral compartment of the knee: a 2 year follow-up study using 3.0 T MRI. Ann Rheum Dis 2013 Jul 19 [Epub ahead of print]

 

Guermazi A, Roemer FW, Felson DT, Brandt KD. Unresolved questions in Rheumatology: Motion for debate: Osteoarthritis clinical trials have not identified efficacious therapies because traditional imaging outcome measures are inadequate. Arthritis Rheum 2013; 65: 2748-2758.

 

Messier SP, Mihalko SL, Beavers DP, Nicklas BJ, Devita P, Carr JJ, Hunter DJ, Williamson JD, Bennell KL, Guermazi A, Lyles M, Loeser RF. Strength Training for Arthritis Trial (START): design and rationale. BMC Musculoskelet Disord 2013; 14: 208.

 

Xu L, Hayashi D, Guermazi A, Hunter DJ, Li L, Winterstein A, Bohndorf K, Roemer FW. The diagnostic performance of radiography for detection of osteoarthritis-associated features compared with MRI in hip joints with chronic pain. Skeletal Radiol 2013; 42: 1421-1428.

 

Guermazi A, Hayashi D, Roemer FW, Felson DT. Osteoarthritis: A review of strenghts and weaknesses of different imaging options. Rheum Dis Clin North Am 2013; 39: 567-591.

 

Guermazi A, Hayashi D, Jarraya M, Roemer FW, Zhang Y, Niu J, Crema MD, Englund M, Lynch JA, Nevitt MC, Torner J, Lewis CE, Felson DT. Medial meniscal root tears are associated with medial meniscal extrusion and medial tibiofemoral cartilage damage – The MOST study. Radiology 2013; 268: 814-821.

 

Hunter D, Eckstein F, Kraus VB, Losina E, Sandell L, Guermazi A. Imaging biomarker validation and qualification report: 6th OARSI Workshop on Imaging in Osteoarthritis combined with 3rd OA Biomarkers Workshop. Osteoarthritis Cartilage 2013; 21: 939-942.

 

Jarraya M, Hayashi D, Roemer FW, Crema MD, Diaz L, Conlin J, Marra MD, Jomaah N, Guermazi A. Radiographically occult and subtle fractures: a pictorial review. Radiol Res Pract 2013; 2013:370169.

 

Felson DT, Niu J, Yang T, Torner J, Lewis CE, Aliabadi P, Sack B, Sharma L, Guermazi A, Goggins J, Nevitt MC; MOST and OAI investigators. Physical activity, alignment and knee osteoarthritis: data from MOST and the OAI. Osteoarthritis Cartilage 2013; 21: 789-795.

 

Ratzlaff C, Guermazi A, Collins J, Katz JN, Losina E, Vanwyngaarden C, Russell R, Iranpour T, Duryea J. A rapid, novel method of volumetric assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis. Osteoarthritis Cartilage 2013; 21: 806-814.

 

Katz JN, Brophy RH, Chaisson CE, de Chaves L, Cole BJ, Dahm, DL; Donnell-Fink LA, Guermazi A, Haas AK, Jones MH, Levy BA, Mandl LA, Martin SD, Marx RG, Miniaci A, Matava MJ, Palmisano J, Reinke EK, Richardson BE, Rome BN, Safran-Norton CE, Skoniecki DJ, Solomon DH, Smith MV, Spindler KP, Stuart MJ, Wright J, Wright RW, Losina E. Surgery versus Physical Therapy for Meniscal Tear and Osteoarthritis. The MeTeOR study. N Engl J Med 2013; 368: 1675-1684.

 

Stefanik JJ, Niu J, Gross KD, Roemer FW, Guermazi A, Felson DT. Using magnetic resonance imaging to determine the compartmental prevalence of knee joint structural damage. Osteoarthritis Cartilage 2013; 21: 695-699.

 

Ruhdorfer A, Dannhauer T, Wirth W, Hitzl W, Kwoh CK, Guermazi A, Hunter DJ, Benichou O, Eckstein F, for the OAI Investigators. Thigh muscle cross-sectional areas and strength in advanced versus early painful osteoarthritis – an exploratory between-knee, within-person comparison in Osteoarthritis Initiative participants. Arthritis Care Res (Hoboken) 2013; 65: 1034-1042.

Guermazi A, Hayashi D, Eckstein F, Hunter DJ, Duryea J, Roemer FW. Imaging of osteoarthritis. Rheum Dis Clin North Am 2013; 39: 67-105.

 

Crema MD, Felson DT, Roemer FW, Niu J, Marra MD, Zhang Y, Lynch JA, El-Khoury GY, Lewis CE, Guermazi A. Peripatellar synovitis: Comparison between non-contrast-enhanced and contrast-enhanced MRI and association with pain. The Most study. Osteoarthritis Cartilage 2013; 21: 413-428.

 

Crema MD, Nogueira-Barbosa MH, Roemer FW, Marra MD, Niu J, Chagas-Neto FA, Gregio-Junior E, Guermazi A. Three-dimensional turbo spin-echo magnetic resonance imaging (MRI) and semiquantitative assessment of knee osteoarthritis: comparison with two-dimensional routine MRI. Osteoarthritis Cartilage 2013; 21: 428-433.

 

Roemer FW, Felson DT, Yang T, Niu J, Crema MD, Englund M, Nevitt MC, Zhang Y, Lynch JA, El Khoury GY, Torner J, Lewis CE, Guermazi A. The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI - The MOST study. Semin Arthritis Rheum 2013; 42: 573-581.

 

Bloecker K, Guermazi A, Wirth W, Benichou O, Kwoh CK, Hunter DJ, Englund M, Resch H, Eckstein F. Tibial coverage, meniscus position, size and damage in knees discordant for joint space narrowing - data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 2013; 21: 419-427.

Hayashi D, Guermazi A, Roemer FW. MRI of osteoarthritis: the challenges of definition and quantification. Semin Musculoskelet Radiol 2012; 16: 419-430.

 

Felson DT, Niu J, Gross KD, Englund M, Sharma L, Cooke TD, Guermazi A, Roemer FW, Segal N, Goggins JM, Lewis CE, Eaton C, Nevitt MC. Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: Findings from MOST and the osteoarthritis initiative. Arthritis Rheum 2013; 65: 355-362.

 

Crema MD, Felson DT, Roemer FW, Wang K, Marra MD, Nevitt MC, Lynch JA, Torner J, Lewis CE, Guermazi A. Prevalent cartilage damage and cartilage loss over time are associated with incident bone marrow lesions in the tibiofemoral compartments: the MOST Study. Osteoarthritis Cartilage 2013; 21: 306-313.

 

Xu L, Su Y, Kienle KP, Hayashi D, Guermazi A, Zhang J, Dai Y, Cheng X. Evaluation of radial distribution of cartilage degeneration and necessity of pre-contrast measurements using radial dGEMRIC in adults with acetabular dysplasia. BMC Musculoskelet Disord 2012; 13: 212.

 

Katz JN, Chaisson CE, Cole B, Guermazi A, Hunter DJ, Jones M, Levy BA, Mandl LA, Martin S, Marx RG, Safran-Norton C, Roemer FW, Skoniecki D, Solomon DH, Spindler KP, Wright J, Wright RW, Losina E. The MeTeOR Trial (Meniscal Tear in Osteoarthritis Research): Rationale and design features. Contemp Clin Trials 2012; 33: 1189-1196.

 

Roemer FW, Felson DT, Wang K, Crema MD, Neogi T, Zhang Y, Nevitt MC, Marra MD, Lewis CE, Torner J, Guermazi A. Co-localisation of non-cartilaginous articular pathology increases risk of cartilage loss in the tibiofemoral joint--the MOST study. Ann Rheum Dis 2013: 72: 942-948.

 

Guermazi A, Niu J, Hayashi D, Roemer FW, Englund M, Neogi T, Aliabadi P, McLennan C, Felson DT. Prevalence of osteoarthritis features on knee MRI in persons with normal posteroanterior knee radiographs. Br Med J 2012 Aug 29; 345: e5339.

 

Hayashi D, Englund M, Roemer FW, Niu J, Sharma L, Felson DT, Crema MD, Marra MD, Segal NA, Lewis CE, Nevitt MC, Guermazi A. Knee malalignment is associated with an increased risk for incident and enlarging bone marrow lesions in the more loaded compartments: the MOST study. Osteoarthritis Cartilage 2012; 20: 1227-1233.

 

Roemer FW, Nevitt MC, Felson DT, Niu J, Lynch JA, Crema MD, Lewis CE, Torner J, Guermazi A. Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral joint - the MOST Study. Osteoarthritis Cartilage 2012; 20: 1391-1398.

 

Roemer FW, Guermazi A. Osteoarthritis year 2012 in review: Imaging. Osteoarthritis Cartilage 2012; 20: 1440-1446.

 

Guermazi A, Vanel D, Rajhi H, Mnif N, Roemer FW. The international skeletal society outreach programme in Tunisia 2011. Skeletal Radiol 2012; 41: 1343-1345.

 

Javaid MK, Kiran A, Guermazi A, Kwoh K, Zaim S, Carbone L, Harris T, McCulloch CE, Arden NK, Lane NE, Felson D, Nevitt M. Individual MRI and radiographic features of knee OA in subjects with unilateral knee pain: Health ABC study. Arthritis Rheum 2012; 64: 3246-3255.

 

Eckstein F, Kwoh CK, Boudreau RM, Wang Z, Hannon MJ, Cotofana S, Hudelmaier MI, Wirth W, Guermazi A, Nevitt MC, John MR, Hunter DJ. Quantitative MRI measures of cartilage predict knee replacement: a case-control study from the Osteoarthritis Initiative. Ann Rheum Dis 2013; 72: 707-714.

 

Segal NA, Kern A, Anderson DD, Niu J, Lynch J, Guermazi A, Torner JC, Brown TD, Nevitt M. Elevated tibiofemoral articular contact stress predicts risk for bone marrow lesions and cartilage damage at 30 months. Osteoarthritis Cartilage 2012; 20: 1120-1126.

 

Crema MD, Roemer FW, Englund M, Wang K, Felson DT, Nevitt MC, Marra MD, Torner J, Lewis CE, Guermazi A. Factors associated with meniscal extrusion in knees with or at risk for osteoarthritis: The multicenter osteoarthritis (MOST) study. Radiology 2012; 264: 494-503.

Hunter DJ, Guermazi A. Imaging techniques in osteoarthritis. PM R 2012; 4(5 Suppl): S68-74.

 

Englund M, Roemer FW, Hayashi D, Crema MD, Guermazi A. Meniscus pathology, osteoarthritis and the treatment controversy. Nature Rev Rheum 2012; 8: 412-419.

 

Sharma L, Chmiel JS, Almagor O, Felson D, Guermazi A, Roemer F, Lewis CE, Segal N, Torner J, Cooke TD, Hietpas J, Lynch J, Nevitt M. The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study. Ann Rheum Dis 2012 May 1 [Epub ahead of print]

 

Xu L, Hayashi D, Roemer FW, Felson DT, Guermazi A. Magnetic Resonance Imaging of Subchondral Bone Marrow Lesions in Association with Osteoarthritis. Semin Arthritis Rheum 2012 Apr 25 [Epub ahead of print]

 

Gross KD, Niu J, Stefanik JJ, Guermazi A, Roemer FW, Sharma L, Nevitt MC, Segal NA, Lewis CE, Felson DT. Breaking the Law of Valgus: the surprising and unexplained prevalence of medial patellofemoral cartilage damage. Ann Rheum Dis 2012 Apr 25 [Epub ahead of print]

 

Hayashi D, Xu L, Roemer FW, Hunter DJ, Li L, Katur AM, Guermazi A. Detection of osteophytes and subchondral cysts in the knee with use of tomosynthesis. Radiology 2012; 263: 206-215

 

Baker KR, Matthan NR, Lichtenstein AH, Niu J, Guermazi A, Roemer F, Grainger A, Nevitt MC, Clancy M, Lewis CE, Torner JC, Felson DT. Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. Osteoarthritis Cartilage 2012; 20: 382-387

 

Hayashi D, Roemer FW, Guermazi A. Osteoarthritis year 2011 in review: imaging in OA--a radiologists' perspective. Osteoarthritis Cartilage 2012; 20: 207-214

 

Roemer FW, Kwoh CK, Hannon MJ, Green SM, Jakicic JM, Boudreau R, Crema MD, Moore CE, Guermazi A. Risk factors for MRI-detected patello-femoral and tibio-femoral cartilage loss during a 6-month period: The JOG study. Arthritis Rheum 2011 Dec 27 doi: 10.1002/art.34353 [Epub ahead of print]

 

Gibson N, Guermazi A, Clancy M, Niu J, Grayson P, Aliabadi P, Roemer F, Felson DT. Relation of hand enthesophytes with knee enthesopathy: Is osteoarthritis related to a systemic enthesopathy? J Rheumatol 2012; 39: 359-364.

 

Guermazi A, Roemer FW, Burstein D, Hayashi D. Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis. Arthritis Res Ther 2011; 13: 247

 

Roemer FW, Guermazi A, Niu J, Zhang Y, Mohr A, Felson DT. Prevalence of MRI-detected cartilage damage and osteophytes: the atrophic and hypertrophic phenotypes of knee osteoarthritis in a population-based cohort. Arthritis Rheum 2012; 64: 429-437.

 

Kim HA, Kim I, Song YW, Kim DH, Niu J, Guermazi A, Crema MD, Hunter DJ, Zhang Y. The association between meniscal and cruciate ligament damage and knee pain in community residents. Osteoarthritis Cartilage 2011; 19:1422-1428

 

Hayashi D, Guermazi A, Kwoh CK, Hannon MJ, Moore C, Jakicic JM, Green SM, Roemer FW. Semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts of the knee at 3T MRI: A comparison between intermediate-weighted fat-suppressed spin echo and Dual Echo Steady State sequences. BMC Musculoskelet Disord 2011;12:198

 

Crema MD, Guermazi A, Sayre EC, Roemer FW, Wong H, Thorne A, Singer J, Esdaile JM, Marra MD, Kopec JA, Nicolaou S, Cibere J. The association of magnetic resonance imaging (MRI)-detected structural pathology of the knee with crepitus in a population-based cohort with knee pain: the MoDEKO study. Osteoarthritis Cartilage 2011; 19:1429-1432

 

Stefanik JJ, Guermazi A, Zhu Y, Zumwalt AC, Gross KD, Clancy M, Lynch JA, Segal NA, Lewis CE, Roemer FW, Powers CM, Felson DT. Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis. Arthritis Care Res (Hoboken) 2011;63:1391-1397

 

Felson DT, Niu J, Guermazi A, Sack B, Aliabadi P. Defining radiographic incidence and progression of knee osteoarthritis: suggested modifications of the Kellgren and Lawrence scale. Ann Rheum Dis 2011;70:1884-1886

 

Roemer FW, Guermazi A, Felson DT, Niu J, Nevitt MC, Crema MD, Lynch JA, Lewis CE, Torner J, Zhang Y. Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study. Ann Rheum Dis 2011;70:1804-1809

 

Roemer FW, Crema MD, Trattnig S, Guermazi A. State of The Art: Advances in imaging of osteoarthritis and cartilage. Radiology 2011;260:332-354

 

 

Guermazi A, Roemer FW, Hayashi D. Imaging of osteoarthritis: update from a radiological perspective. Curr Opin Rheumatol 2011;23:484-491

 

Gross KD, Felson DT, Niu J, Hunter DJ, Guermazi A, Roemer FW, Dufour AB, Gensure RH, Hannan MT. Association of flat feet with knee pain and cartilage damage in older adults. Arthritis Care Res (Hoboken) 2011;63:937-944

 

Stefanik JJ, Roemer FW, Zumwalt AC, Zhu Y, Gross KD, Lynch JA, Frey-Law LA, Lewis CE, Guermazi A, Powers CM, Felson DT. Association between measures of trochlear morphology and structural features of patellofemoral joint osteoarthritis on MRI: The MOST Study. J Orthop Res 2011 Jun 24 [Epub ahead of print]

 

Crema MD, Roemer FW, Guermazi A. Magnetic resonance imaging in knee osteoarthritis research: semiquantitative and compositional assessment. Magn Reson Imaging Clin N Am 2011;19:295-321

 

Englund M, Felson DT, Guermazi A, Roemer FW, Wang K, Crema MD, Lynch JA, Sharma L, Segal NA, Lewis CE, Nevitt MC. Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study. Ann Rheum Dis 2011;70:1733-1739

 

Hunter DJ, Guermazi A, Lo GH, Grainger AJ, Conaghan PG, Boudreau RM, Roemer FW. Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score). Osteoarthritis Cartilage 2011;19:990-1002

 

Hunter DJ, Arden N, Conaghan PG, Eckstein F, Gold G, Grainger A, Guermazi A, Harvey W, Jones G, Hellio Le Graverand MP, Laredo JD, Lo G, Losina E, Mosher TJ,Roemer F, Zhang W; OARSI OA Imaging Working Group. Definition of osteoarthritis on MRI: results of a Delphi exercise. Osteoarthritis Cartilage 2011;19:963-969

 

Habib S, Guermazi A, Ozonoff A, Hayashi D, Crema MD, Roemer FW. MRI-based volumetric assessment of joint effusion in knee osteoarthritis using proton density-weighted fat-suppressed and T1-weighted contrast-enhanced fat-suppressed sequences. Skeletal Radiol 2011;40:1581-1585

 

Crema MD, Hunter DJ, Roemer FW, Li L, Marra MD, Nogueira-Barbosa MH, Hellio Le Graverand MP, Wyman BT, Guermazi A. The relationship between prevalent medial meniscal intrasubstance signal changes and incident medial meniscal tears in women over a 1-year period assessed with 3.0T MRI. Skeletal Radiol 2011;40:1017-1023

 

Roemer FW, Hunter DJ, Winterstein A, Li L, Kim YJ, Cibere J, Mamisch TC, Guermazi A. Hip osteoarthritis MRI scoring system (HOAMS): Reliability and associations with radiographic and clinical findings Osteoarthritis Cartilage 2011;19:946-962

 

Guermazi A, Hunter DJ, Li L, Benichou O, Eckstein F, Kwoh CK, Nevitt MC, Hayashi D. Different thresholds for detecting osteophytes and joint space narrowing exist between the site investigators and the centralized reader in a multicenter knee osteoarthritis study - Data from the Osteoarthritis Initiative. Skeletal Radiol 2011 April 9 [Epub ahead of print]

 

Crema MD, Roemer FW, Hayashi D, Guermazi A. Comment on: Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study. Rheumatology (Oxford) 2011;50:996-997

 

Ip S, Sayre EC, Guermazi A, Nicolaou S, Wong H, Thorne A, Singer J, Kopec JA, Esdaile JM, Cibere J. Frequency of Bone Marrow Lesions and Association with Pain Severity: Results from a Population-based Symptomatic Knee Cohort. J Rheumatol 2011;38:1079-1085

 

Cibere J, Sayre EC, Guermazi A, Nicolaou S, Kopec JA, Esdaile JM, Thorne A, Singer J, Wong H. Natural history of cartilage damage and osteoarthritis progression on magnetic resonance imaging in a population-based cohort with knee pain. Osteoarthritis Cartilage 2011;19:683-688

 

Hayashi D, Guermazi A, Hunter DJ. Osteoarthritis year 2010 in review: imaging. Osteoarthritis Cartilage 2011;19:354-360

 

Hayashi D, Guermazi A, Crema MD, Roemer FW. Imaging in osteoarthritis: what have we learned and where are we going? Minerva Med 2011;102:15-32

 

Hayashi D, Roemer FW, Katur A, Felson DT, Yang SO, Alomran F, Guermazi A. Imaging of Synovitis in Osteoarthritis: Current Status and Outlook. Semin Arthritis Rheum 2011 Feb 2 [Epub ahead of print]

 

Crema MD, Roemer FW, Marra MD, Burstein D, Gold GE, Eckstein F, Baum T, Mosher TJ, Carrino JA, Guermazi A. Articular cartilage in the knee: Current MR imaging techniques and applications in clinical practice and research. RadioGraphics 2011;31:37-62

 

Stein V, Li L, Lo G, Guermazi A, Zhang Y, Kent Kwoh C, Eaton CB, Hunter DJ. Pattern of joint damage in persons with knee osteoarthritis and concomitant ACL tears. Rheumatol Int 2011 Jan 21 [Epub ahead of print]

 

Guermazi A, Roemer FW, Hayashi D, Crema MD, Niu J, Zhang Y, Marra MD, Katur A, Lynch JA, El-Khoury GY, Baker K, Hughes LB, Nevitt MC, Felson DT. Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: The MOST study. Ann Rheum Dis 2011;70:805-811

 

Zhang Y, Nevitt M, Niu J, Lewis C, Torner J, Guermazi A, Roemer F, McCulloch C, Felson D. Fluctuation of knee pain and changes in bone marrow lesions, effusions and synovitis on Magnetic resonance imaging. Arthritis Rheum 2011;63:691-699

 

Felson DT, Lynch J, Guermazi A, Roemer FW, Niu J, McAlindon T, Nevitt MC. Comparison of BLOKS and WORMS scoring systems part II. Longitudinal assessment of knee MRIs for osteoarthritis and suggested approach based on their performance: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage 2010;18:1402-1407

 

Hayashi D, Roemer FW, Dhina Z, Kwoh CK, Hannon MJ, Moore C, Guermazi A. Longitudinal assessment of cyst-like lesions of the knee and their relation to radiographic osteoarthritis and MRI-detected effusion and synovitis in patients with knee pain. Arthritis Res Ther 2010;12:R172

 

Roemer FW, Kwoh CK, Hannon MJ, Crema MD, Moore CE, Jakicic JM, Green SM, Guermazi A. Semiquantitative assessment of focal cartilage damage at 3T MRI: A comparative study of dual echo at steady state (DESS) and intermediate-weighted (IW) fat suppressed fast spin echo sequences. Eur J Radiol 2011;80:e126-131

 

Lynch JA, Roemer FW, Nevitt MC, Felson DT, Niu J, Eaton CB, Guermazi A. Comparison of BLOKS and WORMS scoring systems part I. Cross sectional comparison of methods to assess cartilage morphology, meniscal damage and bone marrow lesions on knee MRI: data from the osteoarthritis initiative. Osteoarthritis Cartilage 2010;18:1393-1401

 

Guermazi A, Hayashi D, Roemer FW, Niu J, Yang M, Lynch JA, Torner JC, Lewis CE, Sack B, Felson DT, Nevitt MC. Cyst-like lesions of the knee joint and their relation to incident knee pain and development of radiographic osteoarthritis: the MOST study. Osteoarthritis Cartilage 2010;18:1386-1392

 

Chang A, Moisio K, Chmiel JS, Eckstein F, Guermazi A, Almagor O, Cahue S, Wirth W, Prasad P, Sharma L. Subregional effects of meniscal tears on cartilage loss over 2 years in knee osteoarthritis. Ann Rheum Dis 2011;70:74-79

 

Hayashi D, Roemer FW, Guermazi A. Choice of pulse sequences for MRI-based semiquantitative assessment of cartilage defects in osteoarthritis research. Arthritis Rheum 2010;62:3830-3831

 

Fotinos-Hoyer AK, Guermazi A, Jara H, Eckstein F, Ozonoff A, Khard H, Norbash A, Bohndorf K, Roemer FW. Assessment of synovitis in the osteoarthritic knee: Comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast-enhanced fat-suppressed T1-weighted MRI. Magn Reson Med 2010;64:604-609

 

Crema MD, Roemer FW, Zhu Y, Marra MD, Niu J, Zhang Y, Lynch JA, Javaid MK, Lewis CE, El-Khoury GY, Felson DT, Guermazi A. Subchondral cystlike lesions develop longitudinally in areas of bone marrow edema-like lesions in Patients with or at risk for knee osteoarthritis: detection with MR imaging--the MOST study. Radiology 2010;256:855-862

 

Eckstein F, Yang M, Guermazi A, Roemer FW, Hudelmaier M, Picha K, Baribaud F, Wirth W, Felson DT. Reference values and Z-scores for subregional femorotibial cartilage thickness--results from a large population-based sample (Framingham) and comparison with the non-exposed Osteoarthritis Initiative reference cohort. Osteoarthritis Cartilage 2010;18:1275-1283

 

Roemer FW, Kassim Javaid M, Guermazi A, Thomas M, Kiran A, Keen R, King L, Arden NK. Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI. Osteoarthritis Cartilage 2010;18:1269-1274

 

Roemer FW, Khrad H, Hayashi D, Jara H, Ozonoff A, Fotinos-Hoyer AK, Guermazi A. Volumetric and semiquantitative assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis: a comparison of contrast-enhanced and non-enhanced imaging. Osteoarthritis Cartilage 2010;18:1062-1066

 

Wirth W, Benichou O, Kwoh CK, Guermazi A, Hunter D, Putz R, Eckstein F; OAI Investigators. Spatial patterns of cartilage loss in the medial femoral condyle in osteoarthritic knees: data from the Osteoarthritis Initiative. Magn Reson Med 2010;63:574-581

 

Cibere J, Zhang H, Thorne A, Wong H, Singer J, Kopec JA, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Association of clinical findings with pre-radiographic and radiographic knee osteoarthritis in a population-based study. Arthritis Care Res (Hoboken) 2010;62:1691-1698

 

Stefanik JJ, Zhu Y, Zumwalt AC, Gross KD, Clancy M, Lynch JA, Frey Law LA, Lewis CE, Roemer FW, Powers CM, Guermazi A, Felson DT. Association between patella alta and the prevalence and worsening of structural features of patellofemoral joint osteoarthritis: the multicenter osteoarthritis study. Arthritis Care Res (Hoboken) 2010;62:1258-1265

 

Benichou OD, Hunter DJ, Nelson DR, Guermazi A, Eckstein F, Kwoh K, Myers SL, Wirth W, Duryea J; Osteoarthritis Initiative Investigators. One-year change in radiographic joint space width in patients with unilateral joint space narrowing: data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken) 2010;62:924-931

 

Kothari A, Guermazi A, Chmiel JS, Dunlop D, Song J, Almagor O, Marshall M, Cahue S, Prasad P, Sharma L. Within-subregion relationship between bone marrow lesions and subsequent cartilage loss in knee osteoarthritis. Arthritis Care Res (Hoboken) 2010;62:198-203

 

Hunter DJ, Losina E, Guermazi A, Burstein D, Lassere MN, Kraus V.

A pathway and approach to biomarker validation and qualification for osteoarthritis clinical trials. Curr Drug Targets 2010;11:536-545

 

Englund M, Guermazi A, Roemer FW, Yang M, Zhang Y, Nevitt MC, Lynch JA, Lewis CE, Torner J, Felson DT. Meniscal pathology on MRI increases the risk for both incident and enlarging subchondral bone marrow lesions of the knee: the MOST Study. Ann Rheum Dis 2010;69:1796-1802

 

Baker K, Grainger A, Niu J, Clancy M, Guermazi A, Crema M, Hughes L, Buckwalter J, Wooley A, Nevitt M, Felson DT. Relation of synovitis to knee pain using contrast-enhanced MRIs. Ann Rheum Dis 2010;69:1779-1783

 

Neogi T, Nevitt MC, Niu J, Sharma L, Roemer F, Guermazi A, Lewis C, Torner J, Javaid K, Felson D. Subchondral bone attrition may be a reflection of compartment-specific mechanical load: The MOST Study.Ann Rheum Dis 2010;69:841-844

 

Crema MD, Roemer FW, Marra MD, Niu J, Lynch JA, Felson DT, Guermazi A. Contrast-enhanced MRI of subchondral cysts in patients with or at risk for knee osteoarthritis: The MOST study. Eur J Radiol 2010;75:e92-96

 

Suri P, Katz JN, Rainville J, Kalichman L, Guermazi A, Hunter DJ. Vascular disease is associated with facet joint osteoarthritis. Osteoarthritis Cartilage 2010;18:1127-1132

 

Eckstein F, Wirth W, Hunter DJ, Guermazi A, Kwoh CK, Nelson DR, Benichou O; for the OAI Investigators. Magnitude and regional distribution of cartilage loss associated with grades of joint space narrowing in radiographic osteoarthritis - data from the Osteoarthritis Initiative (OAI). Osteoarthritis Cartilage 2010;18:760-768

 

Crema MD, Guermazi A, Li L, Nogueira-Barbosa MH, Marra MD, Roemer FW, Eckstein F, Hellio Le Graverand MP, Wyman BT, Hunter DJ. The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period. Osteoarthritis Cartilage 2010;18:336-343

 

Javaid MK, Lynch JA, Tolstykh I, Guermazi A, Roemer F, Aliabadi P, McCulloch C, Curtis J, Felson D, Lane NE, Torner J, Nevitt M. Pre-radiographic MRI findings are associated with onset of knee symptoms: the most study. Osteoarthritis Cartilage 2010;18:323-328

 

Stein V, Li L, Guermazi A, Zhang Y, Kent Kwoh C, Eaton CB, Hunter DJ; for the OAI Investigators. The relation of femoral notch stenosis to ACL tears in persons with knee osteoarthritis. Osteoarthritis Cartilage 2010;18:192-199

 

Roemer FW, Lynch JA, Niu J, Zhang Y, Crema MD, Tolstykh I, El-Khoury GY, Felson DT, Lewis CE, Nevitt MC, Guermazi A. A comparison of dedicated 1.0T extremity MRI vs large-bore 1.5T MRI for semiquantitative whole organ assessment of osteoarthritis: the MOST study. Osteoarthritis Cartilage 2010;18:168-174

 

Roemer FW, Neogi T, Nevitt MC, Felson DT, Zhu Y, Zhang Y, Lynch JA, Javaid MK, Crema MD, Torner J, Lewis CE, Guermazi A. Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study. Osteoarthritis Cartilage 2010;18:47-53

 

Reichenbach S, Yang M, Eckstein F, Niu J, Hunter DJ, McLennan CE, Guermazi A, Roemer FW, Hudelmaier M, Aliabadi P, Felson DT. Does cartilage volume or thickness distinguish knees with and without radiographic osteoarthritis? The Framingham study. Ann Rheum Dis (ARD) 2010;69:143-149

 

Eckstein F, Benichou O, Wirth W, Nelson DR, Maschek S, Hudelmaier M, Kwoh CK, Guermazi A, Hunter D. Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing: Data from the osteoarthritis initiative. Arthritis Rheum 2009;61:1218-1225

 

Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong H, Singer J, Kopec J, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. Arthritis Rheum 2009;60:1372-1380

 

Kalichman L, Suri P, Guermazi A, Li L, Hunter DJ. Facet orientation and tropism: associations with facet joint osteoarthritis and degeneratives. Spine 2009;34:E579-585.

 

Roemer FW, Guermazi A, Zhang Y, Yang M, Hunter DJ, Crema MD, Bohndorf K. Hoffa's fat pad: Evaluation on unenhanced MR images as a measure of patello-femoral synovitis in osteoarthritis. AJR Am J Roentgenol 2009;192:1696-1700

 

Neogi T, Felson D, Niu J, Lynch J, Nevitt M, Guermazi A, Roemer F, Lewis CE, Wallace B, Zhang Y. Cartilage loss occurs in the same subregions as subchondral bone attrition: a within-knee subregion-matched approach from the Multicenter Osteoarthritis Study. Arthritis Rheum 2009;61:1539-1544

 

Moisio K, Eckstein F, Chmiel JS, Guermazi A, Prasad P, Almagor O, Song J, Dunlop D, Hudelmaier M, Kothari A, Sharma L. Denuded subchondral bone and knee pain in persons with knee osteoarthritis. Arthritis Rheum 2009;60:3703-3710

 

Englund M, Guermazi A, Lohmander LS. The meniscus in knee osteoarthritis. Rheum Dis Clin North Am 2009;35:579-590

 

Crema MD, Roemer FW, Marra MD, Guermazi A. Magnetic resonance imaging assessment of subchondral bone and soft tissues in knee osteoarthritis. Rheum Dis Clin North Am 2009;35:557-577

 

Roemer FW, Eckstein F, Guermazi A. Magnetic resonance imaging-based semiquantitative and quantitative assessment in osteoarthritis. Rheum Dis Clin North Am 2009;35:521-555

 

Guermazi A. Preface-osteoarthritis: from the simple X-ray to compositional MRI: what have we learned? Rheum Dis Clin North Am 2009;35:xiii-xiv.

 

Roemer FW, Zhang Y, Niu J, Lynch JA, Crema MD, Marra MD, Nevitt MC, Felson DT, Hughes L, El-Khoury G, Englund M, Guermazi A. Risk factors for MRI-detected rapid cartilage loss of the tibio-femoral joint over a 30-month period: the MOST study. Radiology 2009;252:772-780

 

Englund M, Guermazi A, Lohmander SL. The role of the meniscus in knee osteoarthritis: a cause or consequence? Radiol Clin North Am 2009;47:703-712

 

Crema MD, Roemer FW, Marra MD, Guermazi A. MR imaging of intra- and periarticular soft tissues and subchondral bone in knee osteoarthritis. Radiol Clin North Am 2009;47:687-701

 

Eckstein F, Guermazi A, Roemer FW. Quantitative MR imaging of cartilage and trabecular bone in osteoarthritis. Radiol Clin North Am 2009;47:655-673

 

Roemer FW, Guermazi A. MR imaging-based semiquantitative assessment in osteoarthritis. Radiol Clin North Am 2009;47:633-654

 

Guermazi A. Imaging of osteoarthritis. Preface. Radiol Clin North Am 2009;47:xiii-xvii.

 

Roemer FW, Frobell R, Hunter DJ, Crema MD, Fischer W, Bohndorf K, Guermazi A. MRI-detected subchondral bone marrow signal alterations of the knee joint: terminology, imaging appearance, relevance and radiological differential diagnosis. Osteoarthritis Cartilage 2009;17:1115-1131

 

Guermazi A, Hunter DJ, Roemer FW. Plain radiography and magnetic resonance imaging diagnostics in osteoarthritis: validated staging and scoring. J Bone Joint Surg Am 2009;91 (Suppl 1):54-62

 

Englund M, Guermazi A, Roemer FW, Aliabadi P, Yang M, Lewis CE, Torner J, Nevitt MC, Sack B, Felson DT. Meniscal tear in knee without surgery and the development of radiographic osteoarthritits among middle-aged and eldelry persons: The Multicenter Osteoarthritis Study. Arthritis Rheum 2009;60:831-839

 

Amin S, Baker K, Niu J, Clancy M, Goggins J, Guermazi A, Grigoryan M, Hunter DJ, Felson DT. Quadriceps strength and the risk for cartilage loss and symptom progression of knee osteoarthritis. Arthritis Rheum 2009;60:189-198

 

Roemer FW, Hunter DJ, Guermazi A. Semiquantitative assessment of synovitis in osteoarthritis on non contrast-enhanced MRI. Osteoarthritis Cartilage 2009;17:820-821

 

Guermazi A, Eckstein F, Hellio Le Graverand-Gastineau MP, Conaghan PG, Burstein D, Keen H, Roemer FW. Osteoarthritis: current role of imaging. Med Clin North Am 2009;93:101-126

 

Roemer FW, Guermazi A, Hunter DJ, Niu J, Zhang Y, Englund M, Javaid MK, Lynch JA, Mohr A, Torner J, Lewis CE, Nevitt MC, Felson DT. The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies. Osteoarthritis Cartilage 2009;17:748-753

 

Roemer FW, Hunter DJ, Guermazi A. MRI-based semiquantitative assessment of subchondral bone marrow lesions in osteoarthritis research. Osteoarthritis Cartilage2009;17:414-415

 

Kalichman L, Li L, Kim DH, Guermazi A, Berkin V, O’Donnell CJ, Hoffmann U, Cole R, Hunter DJ. Facet joint osteoarthritis and low back pain in the community-based population. Spine 2008;33:2560-2565

 

Roemer FW, Guermazi A, Javaid MK, Lynch JA, Niu J, Zhang Y, Felson DT, Lewis CE, Torner J, Nevitt MC. Change in MRI–detected subchondral bone marrow lesions is associated with cartilage loss – the MOST study. A longitudinal multicenter study of knee osteoarthritis. Ann Rheum Dis 2009;68:1461-1465

 

Kalichman L, Li L, Kim DH, Guermazi A, Berkin V, O’Donnell CJ, Hoffmann U, Cole R, Hunter DJ. Facet joint osteoarthritis and low back pain in the community-based population. Spine 2008;33:2560-2565

 

Amin S, Baker K, Niu J, Clancy M, Goggins J, Guermazi A, Grigoryan M, Hunter DJ, Felson DT. Quadriceps strength and the risk for cartilage loss and symptom progression of knee osteoarthritis. Arthritis Rheum 2009;60:189-198

 

Roemer FW, Hunter DJ, Guermazi A. Semiquantitative assessment of synovitis in osteoarthritis on non contrast-enhanced MRI. Osteoarthritis Cartilage 2009;17:820-821

 

Guermazi A, Eckstein F, Hellio Le Graverand-Gastineau MP, Conaghan PG, Burstein D, Keen H, Roemer FW. Osteoarthritis: current role of imaging. Med Clin North Am 2009;93:101-126

 

Hunter DJ, Lo GH, Gale D, Grainger AJ, Guermazi A, Conaghan PG. The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston Leeds Osteoarthritis Knee Score). Ann Rheum Dis 2008;67:206-211

 

Englund M, Guermazi A, Gale D, Hunter DJ, Aliabadi P, Clancy M, Felson DT. Incidental meniscal findings on knee MRI in middle-aged and elderly persons. N Engl J Med 2008; 359:1108-1115

 

Roemer FW, Guermazi A, Hunter DJ, Niu J, Zhang Y, Englund M, Javaid MK, Lynch JA, Mohr A, Torner J, Lewis CE, Nevitt MC, Felson DT. The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies. Osteoarthritis Cartilage 2009;17:748-753

 

Roemer FW, Hunter DJ, Guermazi A. MRI-based semiquantitative assessment of subchondral bone marrow lesions in osteoarthritis research. Osteoarthritis Cartilage 2009;17:414-415

 

Roemer FW, Guermazi A, Javaid MK, Lynch JA, Niu J, Zhang Y, Felson DT, Lewis CE, Torner J, Nevitt MC. Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss - the MOST study. A longitudinal multicenter study of knee osteoarthritis. Ann Rheum Dis 2009;68:1461-1465

 

Hunter DJ, LaValley M, Li J, Bauer DC, Nevitt M, Degroot J, Poole R, Eyre D, Guermazi A, Gale D, Totterman S, Felson DT. Biochemical markers of bone turnover and their association with bone marrow lesions. Arthritis Res Ther 2008;10:R102

 

Amin S, Goggins J, Niu J, Guermazi A, Grigoryan M, Hunter DJ, Genant HK, Felson DT. Occupation-related squatting, kneeling, and heavy lifting and the knee joint: a magnetic resonance imaging-based study in men. J Rheumatol 2008;35:1645-1649

 

Sharma L, Eckstein F, Song J, Guermazi A, Prasad P, Kapoor D, Cahue S, Marshall M, Hudelmaier M, Dunlop D. Relationship of meniscal damage, meniscal extrusion, malalignment, and joint laxity to subsequent cartilage loss in osteoarthritic knees. Arthritis Rheum 2008;58:1716-1726

 

Amin S, Guermazi A, LaValley MP, Niu J, Clancy M, Hunter DJ, Grigoryan M, Felson DT. Complete anterior cruciate ligament tear and the risk for cartilage loss and progression of symptoms in men and women with knee osteoarthritis. Osteoarthritis Cartilage 2008;16:897-902

 

Felson DT, Niu J, Guermazi A, Roemer FW, Aliabadi P, Clancy M, Torner J, Lewis CE, Nevitt MC. The development of knee pain correlates with enlarging bone marrow edema lesions on MRI. Arthritis Rheum 2007;56:2986-2992

 

Hernandez-Molina G, Neogi T, Hunter DJ, Niu J, Guermazi A, Roemer FW, McLennan CE, Reichenbach S, Felson DT. The association of bone attrition with knee pain and other MRI features of osteoarthritis. Ann Rheum Dis 2008;67:43-47

 

Reichenbach S, Guermazi A, Niu J, Neogi T, Hunter DJ, Roemer FW, McLennan CE, Hernandez-Molina G, Felson DT. Prevalence of Bone Attrition on Knee Radiographs and MRI in a Community based Cohort. Osteoarthritis Cartilage 2008;16:1005-1010

 

Hernandez-Molina G, Guermazi A, Niu J, Gale D, Goggins J, Amin S, Felson DT. Central bone marrow lesions in symptomatic knee osteoarthritis and their relationship to anterior crucaite ligament tears and cartilage loss. Arthritis Rheum 2008;58:130-136

 

Lo GH, Niu J, McLennan CE, Kiel DP, McLean RR, Guermazi A, Genant HK, McAlindon TE, Hunter DJ. Meniscal damage associated with increased local subchondral bone mineral density: a Framingham study. Osteoarthritis Cartilage 2008;16:261-267

 

Hunter DJ, Li J, LaValley M, Bauer DC, Nevitt M, De Groot J, Poole R, Eyre D, Guermazi A, Gale D, Felson DT. Cartilage markers and their association with cartilage loss on MRI in knee osteoarthritis: The Boston Osteoarthritis Knee Study. Arthritis Res Ther 2007;9:R108

 

Felson DT, Niu J, McClennan C, Sack B, Aliabadi P, Hunter DJ, Guermazi A, Englund M. Knee buckling: prevalence, risk factors, and associated limitations in function. Ann Intern Med 2007;147:534-540

 

Hill CL, Hunter DJ, Niu J, Clancy M, Guermazi A, Genant H, Gale D, Grainger A, Conaghan PG, Felson FT. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Ann Rheum Dis 2007;66:1599-1603

 

Englund M, Niu J, Guermazi A, Roemer FW, Hunter DJ, Lynch JA, Lewis CE, Torner J, Nevitt MC, Zhang YQ, Felson DT. Effect of meniscal damage on the development of frequent knee pain, aching, or stiffness. Arthritis Rheum 2007;56:4048-4054

 

Nevitt NC, Peterfy C, Guermazi A, Felson DT, Duryea J, Woodworth T, Chen H, Kwoh K, Harris TB. Longitudinal performance evaluation and validation of fixed flexion radiography of the knee for detection of joint space loss. Arthritis Rheum 2007;56:1512-1520

 

Issa SN, Dunlop D, Chang A, Song J, Prasad PV, Guermazi A, Peterfy C, Cahue S, Marshall M, Kapoor D, Hayes K, Sharma L. Full-limb and knee radiography assessments of varus-valgus alignment and their relationship to osteoarthritis disease features by magnetic resonance imaging. Arthritis Rheum 2007;57:398-406

 

Felson DT, Niu J, Clancy M, Aliabadi P, Sack B, Guermazi A, Hunter DJ, Amin S, Rogers G, Booth SL. Low levels of vitamin D and worsening of knee OA. Results from two longitudinal studies. Arthritis Rheum 2007;56:129-136

 

Amin S, Niu J, Guermazi A, Grigoryan M, Hunter DJ, Clancy M, LaValley MP, Genant HK, Felson DT. Cigarette smoking and the risk for cartilage loss and knee pain in men with knee osteoarthritis. Ann Rheum Dis 2007;66:18-22

 

Hunter DJ, LaValley M, Li J, Zhang Y, Bauer D, Nevitt M, Guermazi A, De Groot J, Sakkee N, Gale D, Felson DT. Urinary pentosidine does not predict cartilage loss among subjects with symptomatic knee OA: the BOKS Study. Osteoarthritis Cartilage 2007;15:93-97

 

Hunter DJ, Zhang YQ, Tu X, LaValley M, Niu JB, Amin S, Guermazi A, Genant H, Gale D, Felson DT. Change in joint space width: Hyaline articular cartilage loss or alteration of meniscus. Arthritis Rheum 2006;54:2488-2495

 

Hellio Le Graverand MP, Mazzuca S, Lassere M, Guermazi A, Pickering E, Brandt K, Peterfy C, Cline G, Nevitt M, Woodworth T, Conaghan P, Vignon E. Radiography Working Group of the OARSI-OMERACT Imaging Workshop. Assessment of the radioanatomic positioning of the osteoarthritic knee in serial radiographs: comparison of three acquisition techniques. Osteoarthritis Cartilage 2006;14:A37-43

 

Neogi T, Nevitt M, Niu J, LaValley MP, Hunter DJ, Terkeltaub R, Carbone L, Chen H, Harris T, Kwoh K, Guermazi A, Felson DT. Lack of association between chondrocalcinosis and increased risk of cartilage loss in knees with osteoarthritis. Results of two prospective longitudinal magnetic resonance imaging studies. Arthritis Rheum 2006;54:1822-1828

 

Torres L, Dunlop DD, Peterfy CG, Guermazi A, Pottumarthi P, Hayes KW, Song J, Cahue S, Chang A, Marshall M, Sharma L. The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis. Osteoarthritis Cartilage 2006;14:1033-1040

 

Conaghan PG, Tennant A, Peterfy CG, Woodworth T, Stevens R, Guermazi A, Genant H, Felson DT, Hunter D. Examining a whole-organ magnetic resonance imaging scoring system for osteoarthritis of the knee using Rasch analysis. Osteoarthritis Cartilage 2006;14:A116-121

 

Hunter DJ, Conaghan PG, Peterfy CG, Bloch D, Guermazi A, Woodworth T, Stevens R, Genant HK. Responsiveness, effect size, and smallest detectable difference of Magnetic Resonance imaging in knee osteoarthritis. Osteoarthritis Cartilage 2006;14:A112-115

 

Hunter DJ, Zhang Y, Niu J, Goggins J, Amin S, LaValley MP, Guermazi A, Genant H, Gale D, Felson DT. Increase in bone marrow lesions associated with cartilage loss: A longitudinal magnetic resonance study of knee osteoarthritis. Arthritis Rheum 2006;54:1529-1535

 

Hunter DJ, Zhang YQ, Niu JB, Tu X, Amin S, Clancy M, Guermazi A, Grigorian M, Gale D, Felson DT. The association of meniscal pathology with cartilage loss in symptomatic knee osteoarthritis. Arthritis Rheum 2006;54:795-801

 

Amin S, LaValley MP, Guermazi A, Grigoryan M, Hunter DJ, Clancy M, Niu J, Gale DR, Felson DT. The relation of cartilage loss on magnetic resonance imaging and radiographic progression in men and women in knee osteoarthritis. Arthritis Rheum 2005;52:3152-3159

 

Roemer FW, Guermazi A, Lynch JA, Peterfy CG, Nevitt MC, Webb N, Li J, Mohr A, Genant HK, Felson DT. Short tau inversion recovery and proton density-weighted fat suppressed sequences for the evaluation of osteoarthritis of the knee with a 1.0 T dedicated extremity MRI: development of a time-efficient sequence protocol. Eur Radiol 2005;15:978-987

 

Lo GH, Hunter DJ, Zhang Y, McLennan CE, LaValley MP, Kiel DP, McLean RR, Genant HK, Guermazi A, Felson DT. Bone marrow lesions in the knee are associated with increased local bone density. Arthritis Rheum 2005;52:2814-2822

 

Kothari M, Guermazi A, von Ingersleben G, Miaux Y, Sieffert M, Block JE, Peterfy CG. Fixed-flexion radiography of the knee provides reproducible joint space width measurements in osteoarthritis. Eur Radiol 2004;14:1568-1573

 

Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, Genant HK. Whole-organ magnetic resonance imaging score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 2004;12:177-190

 

Guermazi A, Zaim S, Taouli B, Miaux Y, Peterfy CG, Genant HK. MR findings in knee osteoarthritis. Eur Radiol 2003;13:1370-1386