A landmark review on the current and future role of AI in musculoskeletal imaging has been published by Dr. Guermazi in RADIOLOGY, the leading journal in the field of imaging. This paper gives a comprehensive overview of how AI will affect clinical care but also clinical trials. Already MRI examinations have been substantially accelerated by the use of AI and overall volume of imaging will further rapidly increase. A wide variety of AI-based tools can improve the musculoskeletal radiologist’s workflow by triaging imaging examinations, helping with image interpretation, and decreasing the reporting time. Additional AI applications may support business, education, and research purposes. World leaders in the filed have been assembled by Dr. Guermazi to summarize current status and future outlook.