Scientific Articles

BICL's team are leading international scientific researchers. They are consistently publishing the latest findings across all modalities and diseases.

Oncology Scientific Articles


Hayashi D, Tkacz JN, Hammond S, Devenney-Cakir BC, Zaim S, Bouzegaou N, Ounadjela S, Guermazi A. Gastroenteropancreatic neuroendocrine tumors: multimodality imaging features with pathological correlation. Jpn J Radiol 2011;29:85-91

Hayashi D, Devenney-Cakir B, Lee JC, Kim SH, Cheng J, Goldfeder S, Choi BI, Guermazi A. Mucosa-associated lymphoid tissue lymphoma: multimodality imaging and histopathologic correlation. Am J Roentgenol (AJR) 2010;195:W105-117


Hayashi D, Lee JC, Devenney-Cakir B, Zaim S, Ounadjela S, Solal-Céligny P, Juweid M, Guermazi A. Follicular non-Hodgkin's lymphoma. Clin Radiol 2010; 65: 408-420


Deso S, Ludwig B, Kabutey NK, Kim D, Guermazi A. Lymphangiography in the Diagnosis and Localization of Various Chyle Leaks. Cardiovasc Intervent Radiol. 2010 Dec 16. [Epub ahead of print]


Deso S, Kabutey NK, Vilvendhan R, Kim D, Guermazi A. Lymphangiography in the diagnosis, localization, and treatment of a lymphaticopelvic fistula causing chyluria: a case report. Vasc Endovascular Surg. 2010;44:710-713


Yu W, Lin Q, Guermazi A, Shang W. Zhu H, Meng W, Xu R, Zhao Y. Comparison of radiography, CT and MR imaging in detection arthropathies in patients with hemophilia. Haemophilia 2009;15:1090-1096


Juweid ME, Stroobants S, Hoekstra OS, Mottaghy FM, Dietlein M, Guermazi A, Wiseman GA, Kostakoglu L, Scheidhauer K, Buck A, Naumann R, Spaepen K, Hicks R, Weber Wolfgang W, Reske SN, Schwaiger M, Schwartz L, Ziljstra JM, Siegel BA, Cheson BD. Use of positron emission tomography (PET) for response assessment of lymphoma: Consensus of the imaging subcommittee of International Harmonization Project in lymphoma. J Clin Oncol 2007;25:571-578


Guermazi A, Juweid ME. PET poised to alter the current paradigm for response assessment of non-Hodgkin lymphoma. Br J Radiol 2006;79:365-367


Guermazi A, Espérou H, Selimi F, Gluckman E. Imaging of diffuse metastatic and dystrophic pulmonary calcifications in children after haematopoietic stem cell transplantation. Br J Radiol 2005;78:708-713


Guermazi A. Are there other imaging features to differentiate xanthogranulomatous cholecystitis from galbladder carcinoma? Eur Radiol 2005;15:1271-1272


Kothari M, Guermazi A, White D, Suhy J, Reinhold C. Imaging in anti-angiogenesis trial: a clinical trials radiology perspective. Br J Radiol 2004;76 (Suppl 1):92-96


Guermazi A, Brice P, Hennequin C, Sarfati E. Lymphography: an old technique retains its usefulness. Radiographics 2003;23:1541-1558


Chaudhry S, Reinhold C, Guermazi A, Khalili I, Maheshwari S. Benign and malignant diseases of the endometrium. Top Magn Reson Imaging 2003;14:339-357


Guermazi A, Meignin V, Brice P. Extranodal lymphoplasmacytoid lymphoma: spectrum of disease. Eur Radiol 2003;13:771-779


Guermazi A, Feger C, Rousselot P, Merad M, Benchaib N, Bourrier P, Mariette X, Frija J, de Kerviler E. Granulocytic sarcoma (chloroma): imaging findings in adults and children. AJR Am J Roentgenol 2002;178:319-325


Rodallec M, Guermazi A, Brice P, Attal P, Zagdanski AM, Frija J, de Kerviler E. Imaging of MALT lymphoma. Eur Radiol 2002;12:348-356


Guermazi A, Brice P, de Kerviler E, Ferme C, Hennequin C, Meignin V, Frija J. Extranodal Hodgkin disease: spectrum of disease. Radiographics 2001;21:161-179


Guermazi A. Is it wise to eliminate lymphography in the staging of Hodgkin disease? Leukemia Lymphoma 2001;42:655-660


Guermazi A, El Khoury M, Perret F, Meignin V, Masson J, Rili M, Frija J, Espie M. Unusual presentation of thoracic tumors: case 3. Parenchymal lipoma of the lung. J Clin Oncol 2001;19:3784-3786


de Kerviler E, Guermazi A, Zagdanski AM, Meignin V, Gossot D, Oksenhendler E, Mariette X, Brice P, Frija J. Image-guided core-needle biopsy in patients with suspected or recurrent lymphomas. Cancer 2000;89:647-652


Guermazi A, N'guyen Quoc S, Socie G, Briere J, de Kerviler E, Solal Celigny P, Frija J, Rousselot P. Myeloblastoma (chloroma) in leukemia: case 1. Granulocytic sarcoma (chloroma) of the breast. J Clin Oncol 2000;18:3993-3996


Guermazi A, Rili M, Fritsch S, Turki C, Benchaib N, de Kerviler E, Frija J, Sarfati E. Primary malignant melanoma of the esophagus. Ann Chir 2000;125:985-988


Chen GL, Luo Y, Meng X, Qian C, Chen X, Bäuerle T, Schett G, Bozec A. High fat diet exposure predisposes melanoma cells to the bone metastatic niche dependent of interleukin 6 and osteopontin. Oncotarget 2016 Mar 30. doi: 10.18632/oncotarget.8474. [Epub ahead of print]


Hillengass J, Ritsch J, Merz M, Wagner B, Kunz C, Hielscher T, Laue H, Bäuerle T, Zechmann CM, Ho AD, Schlemmer HP, Goldschmidt H, Moehler TM, Delorme S (2016)

Increased microcirculation detected by dynamic contrast-enhanced magnetic resonance imaging is of prognostic significance in asymptomatic myeloma

Br J Haematol 2016 Mar 15. doi: 10.1111/bjh.14038. [Epub ahead of print]


Lips KS, Yanko Ö, Kneffel M, Panzer I, Kauschke V, Madzharova M, Henß A, Schitz P, Rohnke M, Bäuerle T, Liu Y, Kampschulte M, Langheinrich A, Dürselen L, Ignatius A, Heiss C, Schnettler R, Kilian O (2015)

Alterations in bone structure of female alpha7 nicotinic acetylcholine receptor knockout mice

BMC Musculoskeletal Disorders, 16(1):5 (IF=1,9)


Luo Y, Chen GL, Wirtz S, Zech C, Bäuerle T, Munos L, Schett G, Bozec A. (2015)

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche. Cell Metab 2015 Nov 3;22(5):886-94.


Merz M, Moehler TM, Ritsch J, Bäuerle T, Zechmann CM, Wagner B, Jauch A, Hose D, Kunz C, Hielscher T, Laue H, Goldschmidt H, Delorme S, Hillengass J (2015)

Prognostic significance of increased bone marrow microcirculation in newly diagnosed multiple myeloma: Results of prospective DCE-MRI study. Eur Radiol 2015; 26(5):1404-11


Merz M, Seyler L, Bretschi M, Semmler W, Bäuerle T (2015)

Diffusion-weighted imaging and dynamic contrast-enhanced MRI of experimental breast cancer bone metastases - A correlation study with histology. Eur J Radiol 2015; 84(4):623-30


Bäuerle T, Komljenovic D, Merz M, Berger MR, Goodman SL, Semmler W .Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged non-invasively using VCT, MRI and DCE-MRI in a longitudinal in vivo study

Int J Cancer 2011; 47: 2453-2462


Andrulis M, Bäuerle T, Goldschmidt H, Delorme S, Landgren O, Schirmacher P, Hillengass J (2014)

Infiltration patterns in monoclonal plasma cell disorders: correlation of magnetic resonance imaging with matched bone marrow histology

Eur J Radiol, 83:970-974 (IF=2,2)


Bretschi M, Fränzle A, Merz M, Hillengass J, Semmler W, Bendl R, Bäuerle T (2014)

Assessing treatment response of osteolytic lesions by manual volumetry, automatic segmentation and RECIST criteria in experimental bone metastases

Acad Radiol, 21:1177-1184 (IF=2,1)


Fränzle A, Sumkauskaite M, Hillengass J, Bäuerle T, Bendl R (2014)

Fully automated shape model positioning for bone segmentation in whole-body CT scans

J Phys Conf Ser 489: 012029 (open access)


Gordon Y, Partovi S, Müller-Eschner M, Amarteifio E, Bäuerle T, Weber MA, Kauczor HU, Rengier F (2014)

Dynamic contrast-enhanced magnetic resonance imaging: fundamentals and application to the evaluation of the peripheral perfusion

Cardiovasc Diag Ther, 4:147-164


Baccelli I, Schneeweiss A, Sinn P, Stenzinger A, Riethdorf S, Schillert A, Vogel V, Klein C, Bäuerle T, Wallwiener M, Höfner T, Sprick M, Scharpff M, Marmé F, Pantel K, Weichert W, Trumpp A (2013)

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

Nat Biotechnol, 31:539-544 (IF=39,1)


Bäuerle T, Seyler L, Münter M, Jensen A, Brand K, Fritzsche KH, Kopp-Schneider A, Schüssler M, Schlemmer HP, Stieltjes B, Ganten M (2013)

Diffusion-weighted imaging in patients with rectal carcinoma without and after chemoradiotherapy: A comparative study with histology

Eur J Radiol, 82: 444-52 (IF=2,2)


Bretschi M, Cheng C, Komljenovic D, Witt H, Dimitrakopoulou-Strauss A, Strauss LG, Semmler W, Bäuerle T (2013)

Cilengitide affects microenvironment, tumor compartment and vascularization in experimental bone metastases as shown by longitudinal 18F-FDG PET and gene expression analyses

J Cancer Res Clin Oncol, 139: 573-83 (IF=3,0)


Liu Y, Bäuerle T, Pan L, Dimitrakopoulou-Strauss A, Strauss LG, Heiss C, Schnettler R, Semmler W, Cao L (2013)

Calibration of cone beam CT using relative attenuation ratio for quantitative assessment of bone density

Int J Comp Assist Rad Surg, 54: 205-213 (IF=1,7)


Liu Y, Cao L, Heiß C, Hillengass J, Delorme S, Schlewitz G, Schnettler R, Bäuerle T (2013)

Quantitative assessment of microcirculation and diffusion in the bone marrow of osteoporotic rats using VCT, DCE-MRI, DW-MRI, histology and immunohistochemistry

Acta Radiol, 54: 205-213 (IF=1,4)


Liu Y, Cao L, Ray S, Thormann U, Hillengass J, Delorme S, Schnettler R, Alt V, Bäuerle T (2013)

Osteoporosis influences osteogenic but not angiogenic response during bone defect healing in a rat model (2013)

Injury, 44: 923-929 (IF=2,5)


Fränzle A, Bretschi M, Bäuerle T, Giske K, Hillengass J, Bendl R (2013)

A quantification strategy for missing bone mass in case of osteolytic bone lesions

Med Phys, 40: 123501 (IF=3,0)


Merz M, Komljenovic D, Semmler W, Bäuerle T (2012)

Quantitative contrast-enhanced ultrasound for imaging anti-angiogenic treatment response in experimental osteolytic breast cancer bone metastases

Investigative Radiol 47: 422-429 (IF=4,5)


Reufsteck C, Lifshitz-Shovali R, Zepp M, Bäuerle T, Kübler D, Golomb G, Berger MR (2012)

Silencing of skeletal metastasis-associated genes impairs migration of breast cancer cells and reduces osteolytic bone lesions

Clin Exp Metastasis 29: 441-456 (IF=3,7)


Bäuerle T, Komljenovic D, Merz M, Berger MR, Goodman SL, Semmler W  (2011)

Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged non-invasively using VCT, MRI and DCE-MRI in a longitudinal in vivo study

Int J Cancer 47: 2453-2462 (IF=5,0)


Bretschi M, Merz M, Komljenovic D, Berger MR, Semmler W, Bäuerle T (2011)

Cilengitide inhibits metastatic bone colonization in a nude rat model

Oncol Rep 26: 843-851 (IF=2,2)


Cheng C, Komljenovic D, Pan L, Dimitrapopoulou-Strauss A, Strauss LG, Bäuerle T (2011)

Evaluation of treatment response of cilengitide in an experimental model of breast cancer bone metastasis using dynamic PET

Hell J Nucl Med 14: 15-20 (IF=0,9)


Hillengass J, Bäuerle T, Bartl R, Andrulis M, McClanahan F, Laun F, Zechmann C, Shah R, Wagner-Gund B, Simon D, Heiss C, Neben K, Ho AD, Schlemmer HP, Goldschmidt H, Delorme S, Stieltjes B (2011)

Diffusion-weighted imaging for non-invasive and quantitative monitoring of bone marrow infiltration in patients with monoclonal plasma cell disease: A comparative study with histology

Brit J Haematol 153: 721-728 (IF=5,0)


Hillengass J, Bäuerle T, Stieltjes B, McClanahan F, Heiss C, Hielscher T, Wagner-Gund B, Habetler V, Goldschmidt H, Delorme S, Zechmann CM (2011)

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging of bone marrow in healthy individuals

Acta Radiol 52: 324-330 (IF=1,4)


Merz M, Komljenovic D, Zwick S, Semmler W, Bäuerle T (2011)

Sorafenib tosylate and paclitaxel induce anti-angiogenic and subsequent anti-tumor as well as anti-resorptive effects in experimental breast cancer bone metastases

Eur J Cancer 47: 277-286 (IF=4,8)


Mühlhausen U, Komljenovic D, Bretschi M, Leotta K, Eisenhut M, Semmler W, Bäuerle T (2011)

A novel PET tracer for the imaging of αvβ3 and αvβ5 integrins in experimental breast cancer bone metastases

Contrast Media Mol Imaging 6: 413-420 (IF=3,3)


Bäuerle T, Bartling S, Berger MR, Schmitt-Gräff A, Kauczor HU, Delorme S, Kiessling F (2010)

Imaging anti-angiogenic treatment response with DCE-VCT, DCE-MRI and DWI in an animal model of breast cancer bone metastasis

Eur J Radiol 73: 280-287 (IF=2,2)


Bäuerle T, Merz M, Komljenovic D, Zwick S, Semmler W (2010)

Drug induced vessel remodeling in bone metastases as assessed by dynamic contrast enhanced MRI and vessel size imaging - a longitudinal in vivo study

Clinical Cancer Res 16: 3215-3225 (IF=8,2)


Elazar V, Adwan H, Bäuerle T, Golomb G, Berger MR (2010)

Sustained delivery and efficacy of polymeric nanoparticles containing osteopontin and bone sialoprotein antisenses in rats with breast cancer bone metastases

Int J Cancer 126: 1749-1760 (IF=5,0)


Hillengass J, Fechtner K, Weber MA, Bäuerle T, Ayyaz S, Heiss C, Hielscher T, Moehler TM, Egerer G, Neben K, Ho AD, Kauczor HU, Delorme S, Goldschmidt H (2010)

Prognostic significance of whole body magnetic resonance imaging in 250 patients with asymptomatic monoclonal plasma cell disorders

J Clin Oncol 28: 1606-1610 (IF=17,9)


Bäuerle T, Fechtner K, Hillengass J, Zechmann C, Heiss C, Wagner-Gund B, Neben K, Grenacher L, Kauczor HU, Goldschmidt H, Delorme S (2009)

Spinal versus whole body MRI in patients with multiple myeloma and monoclonal gammopathy of undetermined significance

Radiology 252: 477-485 (IF=6,2)


Hillengass J, Zechmann C, Bäuerle T, Wagner-Gund B, Heiss C, Benner A, Ho AD, Neben K, Hose D, Kauczor HU, Goldschmidt H, Delorme S, Moehler TM (2009)

Identification of patients with asymptomatic monoclonal plasma cell disease with pathological microcirculation detected by dynamic contrast-enhanced magnetic resonance imaging

Clin Cancer Res 15: 3118-3125 (IF=8,2)


Bäuerle T, Hilbig H, Bartling S, Kiessling F, Kersten A, Schmitt-Gräff A, Kauczor HU, Delorme S, Berger MR (2008)

Bevacizumab inhibits breast cancer induced osteolysis, surrounding soft tissue metastasis and angiogenesis in rats as visualized by VCT and MRI

Neoplasia 10: 511-520 (IF=5,4)


Peterschmitt J, Bäuerle T, Berger MR (2007)

Effect of zoledronic acid and an antibody against bone sialoprotein II on MDA-MB-231(GFP) breast cancer cells in vitro and on osteolytic lesions induced in vivo by this cell line in nude rats

Clin Exp Metastasis 24: 449-459 (IF=3,7)


Bäuerle T, Peterschmitt J, Hilbig H, Kiessling F, Armbruster FP, Berger MR (2006)

Treatment of bone metastasis induced by MDA-MB-231 breast cancer cells with an antibody against bone sialoprotein

Int J Oncol 28: 573-583 (IF=2,7)


Bäuerle T, Adwan H, Kiessling F, Hilbig H, Armbruster FP, Berger MR (2005)

Characterization of a rat model with site-specific bone metastasis induced by MDA-MB-231 breast cancer cells and its application to the effects of an antibody against bone sialoprotein

Int J Cancer 115: 177-186 (IF=5,0)


Adwan H, Bäuerle T, Berger MR (2004)

Downregulation of osteopontin and bone sialoprotein II is related to reduced colony formation and metastasis formation of MDA-MB-231 human breast cancer cells

Cancer Gene Ther 11: 109-120 (IF=2,6)


Adwan H, Bäuerle T, Najajreh Y, Elazer V, Golomb G, Berger MR (2004)

Decreased levels of osteopontin and bone sialoprotein II are correlated with reduced proliferation, colony formation, and migration of GFP-MDA-MB-231 cells

Int J Oncol 24: 1235-1244 (IF=2,7)


Ellmann S, Beck M, Kuwert T, Uder M, Bäuerle T (2015)

Multimodal Imaging of bone metastases: From preclinical to clinical applications

J Orthop Translation, 3(4): 166–177 (open access)


Bäuerle T, Komljenovic D, Semmler W (2012)

Monitoring molecular, functional and morphologic aspects of bone metastases using non-invasive imaging

Curr Pharm Biotechnol 13: 584-594 (IF=2,5)


Bäuerle T, Komljenovic D, Berger MR, Semmler W (2012)

Multi-modal imaging of angiogenesis in a nude rat model of breast cancer bone metastasis using magnetic resonance imaging, volumetric computed tomography and ultrasound

J Vis Exp 14(66): 4178


Bäuerle T, Semmler W (2009)

Imaging response to systemic therapy in bone metastases.

Eur Radiol 19: 2495-2507 (IF=4,3)

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