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March 12, 2015

In a special Osteoarthritis and Cartilage issue, Dr. Guermazi and Dr. Roemer shape an Imaging atlas for eligibility and on-study safety of potential joint adverse events in anti-NGF studies.  Recently, monoclonal antibodies that bind and inhibit nerve growth factor (a-NGF) have been introduced for treatment of OA symptoms and have shown good analgesic efficacy and improvement in function in patients with OA. However, despite initial promising data a-NGF trials in OA had been suspended due to concerns over accelerated rates of OA progression and other complications such as subchondral insufficiency fracture and osteonecrosis. Since a-NGF therapies offer potential as the first new class of analgesics for many years, future studies assessing a-NGF compounds will have to include stringent eligibility criteria and will require a rigorous safety monitoring. Imaging will play a crucial role in clinical trials to define eligibility of potential participants with focus on exclusion criteria and...

December 3, 2014

CHICAGO – A popular surgery to repair meniscal tears may increase the risk of osteoarthritis and

cartilage loss in some patients, according to research presented today at the annual meeting of the

Radiological Society of North America (RSNA). The findings show that the decision for surgery requires careful consideration in order to avoid accelerated disease onset, researchers said.  

The new study focused on the meniscus, a wedge-shaped piece of cartilage in the knee that acts as a shock absorber between the femur, or thighbone, and tibia, or shinbone.  The two menisci in each knee also play an important role in joint stability. Meniscal tears are among the most common knee injuries, and surgery is often performed to alleviate pain.  "Meniscal surgery is one of the most common orthopedic procedures performed to alleviate pain and improve joint function," said Frank W. Roemer, M.D., from Boston University School of Medicine in Boston and the University of Erlangen-Nuremberg...

September 12, 2014

Magnetic resonance imaging detects significant structural joint damage several years before radiographic knee osteoarthritis is apparent, according to study conducted by BICL Frank Roemer, MD. During a Clinical Science Session, Dr. Frank Roemer will report the findings of a nested case-control study looking to see if preradiographic damage could be observed on MRI and if so, how the severity of this damage might influence the risk of incident radiographic knee OA.

August 29, 2014 is based on a brief work intended as a tool for daily musculoskeletal practice which was first published in 2002. Short paragraphs and simple drawings covered the basic facts of musculoskeletal MRI. Positive feedback over the years suggested that many radiologists prefer this concise style over the usual exposition of textbooks. The success of this early effort lead us to extend the concept of short text passages with accompanying drawings into an expanded—yet still concise—text with many images to illustrate the discussion. Maintaining the original concept, the text passages are deliberately very short and focus on the clinically relevant facts.

The Concept covers all aspects of musculoskeletal MRI with an emphasis on orthopedics and sports medicine. The text is highly compressed and enhanced by the images. Examples of some complex pathologies are included, but without straying from the subject. Learning in radiology, like all learning, is a combin...

July 25, 2014

This year the Internatioal Workshop On Osteoarthritis Imaging received a record-breaking number of abstracts and 14 countrires were represented in attendance. 

IWOAI started in 2007 and was held in Ainring, Germany, with 126 registered participants from academia, regulatory and funding agencies, and industry. Since then, the Workshop has been held annually at various locations, historically alternating between the European and North American locations. 

This workshop is a unique opportunity for scientists, researchers, regulatory agencies, interested members of pharmaceutical companies and others to meet and have an in depth and open minded discussion about the best way to advance the field of osteoarthritis imaging.

"For years, we have been trying to understand osteoarthritis from the imaging point of view. We now have a large amount of imaging and clinical data available on osteoarthritis and it is an optimal time to move forward and expand on our understanding of the dis...

March 5, 2014

Dr. Guermazi joins an esteemed group in the publishing of the latest in Diagnostic Imaging.Over the past decade, PET-CT has achieved great success owing to its ability to simultaneously image structure and function, and show how the two are related. More recently, PET-MRI has also been developed, and it represents an exciting novel option that promises to have applications in oncology as well as neurology. The first part of this book discusses the basics of these dual-modality techniques, including the scanners themselves, radiotracers, scan performance, quantitation, and scan interpretation. As a result, the reader will learn how to perform the techniques to maximum benefit. The second part of the book then presents in detail the PET-CT and PET-MRI findings in cancers of the different body systems. The final two chapters address the use of PET/CT in radiotherapy planning and examine areas of controversy. The authors are world-renowned experts from North America, Europe, and Australia,...

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BICL Director of Research and CMO Dr. Roemer making headlines with new MRI Knee OA Studies.

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